钱萍

个人基本简介

职称：教授

学位：理学博士

毕业院校：辽宁师范大学

电子邮件：qianp@sdau.edu.cn

钱萍，教授，博士生导师。讲授本科生的《无机及分析化学1》、《基础化学实验1&2》、《结构化学》和研究生的《高等物理化学》等课程。曾获校第四届青年教师讲课技能比赛一等奖第一名、山东省首届微课比赛三等奖。先后主持国家自然科学基金和山东省自然科学基金，以第一作者或通讯作者在《ACS Catalysis》，《Journal of Chemical Theory and Computation》，《Journal of Chemical Information and Modeling》，《Communication Chemistry - Nature》，《Protein Science》等国际著名期刊上发表SCI论文40余篇。

主要经历

学科方向

蛋白质的计算机模拟

粘土-水分子体系的力场模型建立及分子动力学模拟研究

团簇的从头计算研究

荣誉获奖

2022-06  山东农业大学2022届优秀学士学位论文指导教师

2021-09  山东农业大学“教学质量奖”二等奖

2018-09  山东农业大学“我最喜欢的专业课老师”荣誉称号

2018-06  山东农业大学2018届优秀学士学位论文指导教师

2013-09  山东农业大学第二届教学先锋先进个人

2013-08  山东省高等学校教师首届微课教学比赛三等奖

2012-09  山东农业大学第四届青年教师讲课技能比赛一等奖

2011-03  山东农业大学“巾帼建功先进个人”荣誉称号

2009-12  山东农业大学第一届青年教师讲课技能比赛二等奖

科研项目

国家自然科学基金面上项目：基于极化力场和多尺度模拟研究组蛋白翻译后修饰crosstalk对Dot1/Dot1L酶活性的调控机制，2022.01-2025.12主持

国家自然科学基金青年项目：粘土-水分子体系力场模型的建立与分子动力学模拟，2010.01-2012.12 主持

山东省自然科学基金面上项目：基于多尺度模拟和生物学实验研究组蛋白泛素化修饰对 Dot1L 甲基化活性的调控机制，2022.01-2024.12主持

山东省自然科学基金面上项目：蛋白质精氨酸甲基转移酶产物特异性的理论模拟与实验研究，2017.08-2020.06主持

代表论著

Deng H, Ma Y, Ren WS, Vuong VQ, Qian P*, Guo H* Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation. ACS Catalysis 2020, 10: 13314-13322. (Top 1区，IF=13.70)

Zhao YY, Xu XL, Deng H, Wang KN, Rahman A, Ma Y, Shaik F, Wang CM, Qian P*, Guo H* Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β Actin H73K Peptide: Insights from a QM/MM Study. Journal of Chemical Theory and Computation 2023, 19: 349-362. (Top 1区，IF=6.578)

Ren WS, Rahman A, Jiang KB, Deng H, Zhao YY, Zhang WJ, Liu K, Qian P*, Guo H*, Unraveling the Origins of Changing Product Specificity Properties of Arginine Methyltransferase PRMT7 by the E181D and E181D/Q329A Mutations through QM/MM MD and Free-Energy Simulations. Journal of Chemical Theory and Computation 2022, 18, 2631-2641. (Top 1区，IF=6.578)

Ren WS, Jiang KB, Deng H, Lu N, Yu T, Guo H*, Qian P* Catalytic Mechanism and Product Specificity of Protein Arginine Methyltransferase PRMT7: A Study from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Theory and Computation 2020, 16, 5301-5312. (Top 1区，IF=6.578)

Qian P*, Guo HB, Wang L, Guo H* QM/MM Investigation of Substrate and Product Specificities of Suv420h2: How Does This Enzyme Generate Dimethylated H4K20 from Monomethylated Substrate? Journal of Chemical Theory and Computation 2017, 13: 2977-2986. (Top 1区，IF=6.578)

Hintzen JCJ, Ma H, Deng H, Witecha A, Andersen SB, Drozak J, Guo H, Qian P*, Li H*, Mecinović J* Histidine Methyltransferase SETD3 Methylates Structurally Diverse Histidine Mimics in Actin. Protein Science 2022, 31: e4305. (2区，IF=6.993)

Al Temimi AHK, Amatdjais-Groenen HIV, Vijayendar Reddy Y, Blaauw RH, Guo H, Qian P*, Mecinović J* The Nucleophilic Amino Group of Lysine is Central for Histone Lysine Methyltransferase Catalysis. Communications Chemistry – Nature 2019, 2: 112. (2区，IF=7.211)

Al Temimi AHK, van der Wekken-de Bruijne R, Proietti G, Guo H, Qian P*, Mecinović J* γ Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones. Bioconjugate Chemistry 2019, 30, 1798-1804. (2区，IF=6.069)

Yue YF, Ma Y, Qian P*, Guo H* Catalytic Mechanism of the Ubiquitin-Like NEDD8 Transfer in RING E3-E2∼NEDD8-Target Complex from QM/MM Free Energy Simulations. Journal of Chemical Information and Modeling, 2018, 58: 422-429. (2区，IF=6.162)

Qian P*, Guo HB, Yue YF, Wang L, Yang XH, Guo H* Understanding the Catalytic Mechanism of Xanthosine Methyltransferase in Caffeine Biosynthesis from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Information and Modeling 2016, 56: 1755-1761. (2区，IF=6.162)