Fu-She Han, PhD
Email: fshan@sdau.edu.cn
Research topics: Total synthesis of natural products; development of new synthetic methodologies.
Education and professional experiences:
1989/09-1993/07: School of Chemistry, Chongqing University (B.S.);
1993/09-1996/07: Department of Organic Chemistry, Dalian Universityof Technology (M.S.);
1996/09-1999/09: Changchun Institute of Applied Chemistry,Chinese Academy of Sciences (Ph.D.);
1999/10-2001/07: Department of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (Postdoc);
2001/08-2003/03: Department of Applied Chemistry, Faculty of Engineering, Ehime University, Japan (Postdoc);
2003/04–2006/03: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan (JST Fellowship; Research Associate);
2006/04–2008/07 the National Institute for Material Sciences, Japan(Researcher);
2008/08-2025/11Changchun Institute of Applied Chemistry, Chinese Academy of Science (Professor);
2025/11-present: College of Chemistry and Material Science, Shandong Agricultural University (Professor).
Representative Publications:
1. “Catalytic Asymmetric Total Synthesis of (+)-Chamaecydin and (+)-Isochamaecydin and their Stereoisomers”, Y.-H. Zhang, L.-H. Deng, D.-X. Tan*, F.-S. Han*, Angew. Chem. Int. Ed., 2025, 64, e202423944 (Highlighted by SYNFACTS).
2. “Enantioselective Total Syntheses of Melotenine-, Voacafrine-, and Tabersonine-Type Aspidosperma Indole Alkaloids”, D.-X. Tan, J. Zhou, C.-Y. Gu, Z.-Y. Li, Y.-J. Shen, F.-S. Han*, Chem.,2025, 11, 102440.
3.“The Phosphinamide-Based New Catalysts and Reaction Methodologies: Discovery and Applications in Natural Product Synthesis”, G.-J. Wu#, D.-X. Tan#, F.-S. Han*, Acc. Chem. Res.2021, 54, 4354. (Invited account).
4. “Desymmetric Enantioselective Reduction of Cyclic 1,3-Diketones Catalyzed by a Recyclable P-Chiral Phosphinamide Organocatalyst”, X.-L. Qin, A. Li, F.-S. Han*,J. Am. Chem. Soc., 2021, 143, 2994. (Highlighted by SYNFACTS).
5. “A Divergent Enantioselective Total Synthesis of Post-Iboga Indole Alkaloids” J. Zhou,# D.-X. Tan,#F.-S. Han*,Angew. Chem. Int. Ed., 2020, 59, 18731. (Highlighted by SYNFACTS).
6. “Enantioselective Total Synthesis and Absolute Configuration Assignment of (+)-Tronocarpine Enabled by an Asymmetric Michael/Aldol Reaction”, D.-X. Tan,# J. Zhou,# C.-Y. Liu, F.-S. Han*,Angew. Chem. Int. Ed., 2020, 59, 3834 (Selected as Frontispiece Cover).
7. “Total Synthesis of Cyrneines A, B, and Glaucopine C”, G.-J. Wu, Y.-H. Zhang, D.-X. Tan, F.-S. Han*, Nat. Commun., 2018, 9, 2148 (Highlighted by SYNFACTS).
8. “Palladium-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C–H Arylation”, Z.-J. Du,# J. Guan,# G.-J. Wu, P. Xu, L.-X. Gao,F.-S. Han*,J. Am. Chem. Soc., 2015, 137, 632. (Highlighted by SYNFACTS).
9. “Enantioselective Total Synthesis and Absolute Configuration Assignment of (+)-Toxicodenane A”, X.-L. Qin, G.-J. Wu, F.-S. Han*, Org. Lett., 2021, 23, 8570. (Highlighted by Synfacts, ChemistryViews, and Org. Chem. Highlights. The top 20 most download articles in Nov. 2021).
10. “Transition-Metal-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: A Remarkable Advance from Palladium to Nickel Catalysts”, F.-S. Han*,Chem. Soc. Rev., 2013, 42, 5270. (Invited review, top 1% of highly cited authors in 2014).
